نوع مقاله : مقاله کامل علمی - پژوهشی
نویسندگان
1 دانشگاه علوم پزشکی آزاد اسلامی
2 گروه علوم پایه، دانشکده داروسازی و علوم دارویی، علوم پزشکی تهران، دانشگاه آزاد اسلامی، تهران، ایران
3 موسسه تحقیقات علوم شیلاتی کشور
چکیده
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Background and Aim: Zolpidem and Passiflora incarnata can do calming and sleep-inducing effects by affecting GABA, which is one of the known brain neurotransmitters. There are evidences that GABA receptors exist in the body's endocrine glands, including the ovary.
Materials and Methods: 120 pieces of Trichogaster trichopterus with an average weight of 2.76 ± 0.49 g were purchased. The fishes were divided into 8 treatments, each treatment containing 15 fishes, the control groups were: Intact and solvent, three treatment groups which received zolpidem with a dose of 5, 10 and 20 mg/kg and three treatment groups receiving Passiflora incarnata extract with doses of 25, 50, and 100 mg/kg . Intramuscular injection was done every other day to reduce stress on the fish for twenty days. Then the fishes were dissected and the ovarian tissue was separated for examination with light and electron microscope and steroid hormones were measured.
Results: The results showed that 17-beta-estradiol hormone increased in all doses of zolpidem and decreased in all doses of Passiflora incarnata extract compared to the control groups (p≤0.05).
In all three doses of zolpidem, the oocytes were mostly in the vitellogenic phase compared to the control group.
Conclusion: while in the treated fish in all three doses of Passiflora incarnata, they were mostly in the prenuclear phase.
کلیدواژه‌ها [English]
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