مروری بر خواص ضد انعقادی و ضد سرطانی پلی ساکارید فوکوئیدان، استخراج شده از جلبک های قهوه ای

نوع مقاله : مقاله کامل علمی - پژوهشی

نویسندگان

1 دانشجوی دکتری گروه شیلات، دانشکده منابع طبیعی، دانشگاه تهران، کرج، ایران

2 موسسه تحقیقات علوم شیلاتی کشور، پژوهشکده آبزی‌پروری آبهای داخلی، سازمان تحقیقات، آموزش و ترویج جهاد کشاورزی، بندر انزلی

چکیده

جلبک‌ها یکی از مهم‌ترین منابع طبیعی ارزشمند در جهان به شمار می‌روند. این موجودات دارای ترکیبات زیست‌فعال هستند که در زمینه‌های پزشکی و داروسازی بسیار مورد استفاده قرار گرفته‌اند. فوکوئیدان یکی از پلی‌ساکاریدهای سولفاته محسوب می‌شود که از جلبک‌های دریایی و عمدتاً از جلبک‌های قهوه‌ای استخراج می‌شود. در سال های اخیر، این پلی‌ساکارید به‌عنوان یک عامل ضد انعقادی و ضد سرطانی شناخته شده است. خوشبخاته کشور ایران به دلیل برخورداری از برخی از گونه‌های جلبک قهوه‌ای نظیر جنس سارگاسوم، پتانسیل زیادی برای استخراج این ترکیب ارزشمند دارد. بررسی خواص درمانی فوکوئیدان می‌تواند جنبه های متعددی از فعالیت‌های بیولوژیکی این ترکیب مهم را آشکار سازد. مطالعه حاضر که با هدف بررسی فعالیت‌های ضدانعقادی و ضدسرطانی پلی‌ساکارید فوکوئیدان صورت گرفته است، می‌تواند در انعکاس خواص و فعالیت‌های بیولوژیکی این پلی‌ساکارید ارزشمند کارساز و مثمر ثمر باشد.

کلیدواژه‌ها


عنوان مقاله [English]

A review of anticoagulant and anticancer properties of fucoidan polysaccharide extracted from brown algae

نویسندگان [English]

  • Ali Reza Radkhah 1
  • Esmail Sadeghinejad Masouleh 2
1 Department of Fisheries, Faculty of Natural Resources, University of Tehran, Karaj, Iran
2 Iranian fisheries Science Research Institute, Inland Water Aquaculture Center, Agricultural Research Education and Extension Organization (AREEO), Anzali, Iran
چکیده [English]

Algae are one of the most valuable natural resources in the world. These organisms have bioactive compounds that are widely used in medical and pharmaceutical fields. Fucoidan is one of the sulfated polysaccharides that is extracted from marine algae, mainly from brown algae. In recent years, it has been identified as an anticoagulant and anticancer agent. Due to the presence of some species of brown algae such as the genus Sargassum, Iran has a lot of potential for extracting this valuable compound. The study of the therapeutic properties of fucoidan can reveal several aspects of the biological activity of this important compound. Therefore, the present study aimed to evaluate the anticoagulant and anti-cancerous properties of fucoidan polysaccharide. This study can be useful in reflecting the biological properties of this polysaccharide.

کلیدواژه‌ها [English]

  • Fucoidan
  • polysaccharide
  • Brown algae
  • Anticoagulant
  • Anticancer
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