مروری بر خواص سیتوتوکسیک (ضدسرطان) اسفنج های دریایی

نوع مقاله : مقاله کامل علمی - پژوهشی


1 Iranian Fisheries Research Institute, Persian Gulf and Oman Sea Ecological Research, Agricultural Research,Education and Extension Organization(AREEO), Bandar Abbas, Iran.

2 عضو هیئت علمی


زیست فناوری داروهای دریایی یکی از راه های نوین توسعه و تولید محصولات جدید دارویی از آبزیان است. سرطان یکی از بیماری های شایع و علت اصلی مرگ و میر است، بررسی های شیمیایی و بیولوژیکی اسفنج ها را منبع غنی از ترکیبات ضدسرطانی(سیتوتوکسیک) نشان داده است. در رابطه با خواص سیتوتوکسیک اسفنج ها مطالعات گسترده ایی به ویژه در کشوهای آمریکایی و اروپایی انجام شده است، از دهه گذشته تا کنون مطالعات روی اسفنج های آب های خلیج فارس و دریای عمان درحال انجام است. نتایج این بررسی ها نشان می دهد که اسفنج های؛ Iophon sp.، Dysidea pallescens ، Ircinia echinata، Dysidea avara، Axinella sinoxeaisوIrcinaspp. از جزایر و آب های خلیج فارس دارای اثرات سیتوتوکسیک روی رده های سلول های سرطانی است. با توجه به خواص سیتوتوکسیک (ضدسرطان) اسفنج های دریایی که در بسیاری از نقاط جهان اثبات شده است و از طرف دیگر تنوع و فراوانی گونه های اسفنج در آب های خلیج فارس و دریای عمان در این بررسی علمی به بررسی خواص سیتوتوکسیک اسفنج های دریایی با تأکید بر اسفنج های مطالعه شده در خلیج فارس پرداخته شده است.



عنوان مقاله [English]

Review of the cytotoxic activity (anticancer) of marine sponges

نویسنده [English]

  • Melika Nazemi 1
1 Iranian Fisheries Research Institute, Persian Gulf and Oman Sea Ecological Research, Agricultural Research,Education and Extension Organization(AREEO), Bandar Abbas, Iran.
چکیده [English]

Marine drugs are one of the new ways of the development and manufacture of pharmaceutical products from aquaculture. Cancer is one of the common diseases and the main cause of death in the world. Biological and chemical reviews of sponges have shown that they are a rich source of anticancer compounds. In the case of cytotoxic effect of sponges extensive studies have been done especially in American and European countries. A lot of studies on the Persian Gulf and Oman Sea on sponges are in progress from past decade. The results of this evaluation indicate that sponges: Iophon sp.، Dysidea pallescens ، Ircinia echinata، Dysidea avara، Axinella sinoxeais and Ircina spp of the Persian Gulf and its Islands have cytotoxic effects on cancer cell lines. The cytotoxic properties of marine sponges, it has been proved in many parts of the world and on the other hand, the diversity and abundance of sponge species in the Persian Gulf and Oman Sea reviewed in this scientific evaluation and examined the cytotoxic properties of the marine sponge with emphasis on the sponge in the Persian Gulf.

کلیدواژه‌ها [English]

  • Sponge
  • natural products
  • cytotoxic activity
  • Persian Gulf
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