مروری بر خواص سیتوتوکسیک (ضدسرطان) اسفنج های دریایی

نوع مقاله: مقاله علمی - پژوهشی


1 Iranian Fisheries Research Institute, Persian Gulf and Oman Sea Ecological Research, Agricultural Research,Education and Extension Organization(AREEO), Bandar Abbas, Iran.

2 عضو هیئت علمی


زیست فناوری داروهای دریایی یکی از راه های نوین توسعه و تولید محصولات جدید دارویی از آبزیان است. سرطان یکی از بیماری های شایع و علت اصلی مرگ و میر است، بررسی های شیمیایی و بیولوژیکی اسفنج ها را منبع غنی از ترکیبات ضدسرطانی(سیتوتوکسیک) نشان داده است. در رابطه با خواص سیتوتوکسیک اسفنج ها مطالعات گسترده ایی به ویژه در کشوهای آمریکایی و اروپایی انجام شده است، از دهه گذشته تا کنون مطالعات روی اسفنج های آب های خلیج فارس و دریای عمان درحال انجام است. نتایج این بررسی ها نشان می دهد که اسفنج های؛ Iophon sp.، Dysidea pallescens ، Ircinia echinata، Dysidea avara، Axinella sinoxeaisوIrcinaspp. از جزایر و آب های خلیج فارس دارای اثرات سیتوتوکسیک روی رده های سلول های سرطانی است. با توجه به خواص سیتوتوکسیک (ضدسرطان) اسفنج های دریایی که در بسیاری از نقاط جهان اثبات شده است و از طرف دیگر تنوع و فراوانی گونه های اسفنج در آب های خلیج فارس و دریای عمان در این بررسی علمی به بررسی خواص سیتوتوکسیک اسفنج های دریایی با تأکید بر اسفنج های مطالعه شده در خلیج فارس پرداخته شده است.



عنوان مقاله [English]

Review of the cytotoxic activity (anticancer) of marine sponges

نویسنده [English]

  • Melika Nazemi 1

1 Iranian Fisheries Research Institute, Persian Gulf and Oman Sea Ecological Research, Agricultural Research,Education and Extension Organization(AREEO), Bandar Abbas, Iran.

چکیده [English]

Marine drugs are one of the new ways of the development and manufacture of pharmaceutical products from aquaculture. Cancer is one of the common diseases and the main cause of death in the world. Biological and chemical reviews of sponges have shown that they are a rich source of anticancer compounds. In the case of cytotoxic effect of sponges extensive studies have been done especially in American and European countries. A lot of studies on the Persian Gulf and Oman Sea on sponges are in progress from past decade. The results of this evaluation indicate that sponges: Iophon sp.، Dysidea pallescens ، Ircinia echinata، Dysidea avara، Axinella sinoxeais and Ircina spp of the Persian Gulf and its Islands have cytotoxic effects on cancer cell lines. The cytotoxic properties of marine sponges, it has been proved in many parts of the world and on the other hand, the diversity and abundance of sponge species in the Persian Gulf and Oman Sea reviewed in this scientific evaluation and examined the cytotoxic properties of the marine sponge with emphasis on the sponge in the Persian Gulf.

کلیدواژه‌ها [English]

  • Sponge
  • natural products
  • cytotoxic activity
  • Persian Gulf
kit-text-size-adjust: auto; -webkit-te1. Barrero, A.F., Alvarez-Manzaneda, E.J., Chahboun, R., Cortés, M., and
Armstrong, V. 1999. Synthesis and antitumor activity of puupehedione and
related compounds. Tetrahedron. 55(52): 15181-15208.
2. Blackburn, C.L., Hopmann, C., Sakowicz, R., Berdelis, M.S., Goldstein, L.S.,
and Faulkner, D.J. 1999. Adociasulfates 1-6, Inhibitors of Kinesin Motor
Proteins from the Sponge Haliclona (aka Adocia) sp. The Journal of organic
chemistry, 64(15): 5565-5570.
3. Campbell, A.C., and Dawes, J. 2005. The Encyclopedia of underwater life:
Oxford University Press. 586p.
4. Datta, D., Talapatra, S., and Swarnakar, S. 2015. Bioactive compounds from
marine invertebrates for potential medicines-an overview. International Letters
of Natural Sciences 7.
5. Dickson, D.P., and Wardrop, D.J. 2009. Total synthesis of (±)-agelastatin A, a
potent inhibitor of osteopontin-mediated neoplastic transformations. Organic
letters 11(6): 1341-1344.
6. Djura, P., Stierle, D.B., Sullivan, B., Faulkner, D.J., Arnold, E.V., and J.
Clardy. 1980. Some metabolites of the marine sponges Smenospongia aurea and
Smenospongia (ident. Polyfibrospongia) echina. The Journal of organic
chemistry 45(8): 1435-1441.
7. Endo, T., Tsuda, M., Fromont, J., and Kobayashi, J.I. 2007. Hyrtinadine A, a
Bis-indole Alkaloid from a Marine Sponge⊥. Journal of natural products 70(3):
8. Gordaliza, M. 2010. Cytotoxic terpene quinones from marine sponges. Marine
Drugs. 8(12): 2849-2870.
9. Hassan, W., Edrada, R., Ebel, R., Wray, V., Berg, A., Van Soest, R.,
Wiryowidagdo, S., and Proksch, P. 2004. New Imidazole Alkaloids from the
Indonesian Sponge Leucetta c hagosensis. Journal of natural products 67(5):
10.Hooper, J.N., and Van Soest, R.W. 2002. Systema Porifera. A guide to the
classification of sponges: Springer.
11.Iwashima, M., Terada, I., Iguchi, K., and Yamori, T. 2002. New biologically
active marine sesquiterpenoid and steroid from the okinawan sponge of the
genus Axinyssa. Chemical and pharmaceutical bulletin 50(9): 1286-1289.
12.Joseph, B., and Sujatha, S. 2011. Pharmacologically important natural products
from marine sponges. J. Nat. Prod 4: 5-12.
13.Kijjoa, A., and Sawangwong, P. 2004. Drugs and cosmetics from the sea.
Marine Drugs. 2(2): 73-82.
14.Liu, H., Wang, G., Namikoshi, M., Kobayashi, H., Yao, X., and Cai, G. 2006.
Sesquiterpene quinones from a marine sponge Hippospongia sp. that inhibit
maturation of starfish oocytes and induce cell cycle arrest with HepG2 cells.
Pharmaceutical biology. 44(7): 522-527.
15.Mahdian, D., Iranshahy, M., Shakeri, A., Hoseini, A., Yavari, H., Nazemi, M.,
and Iranshahi, M. 2015. Cytotoxicity evaluation of extracts and fractions of five
marine sponges from the Persian Gulf and HPLC fingerprint analysis of
cytotoxic extracts. Asian Pacific Journal of Tropical Biomedicine 5(11): 896-
16.Monaco, R., and Quinlan, R. 2014. Novel Natural Product Discovery from
Marine Sponges and their Obligate Symbiotic Organisms. bio Rxiv: 005454.
17.Mol, V.L., Raveendran, T., Abhilash, K., and Parameswaran, P. 2010.
Inhibitory effect of Indian sponge extracts on bacterial strains and larval
settlement of the barnacle, Balanus amphitrite. International Biodeterioration &
Biodegradation 64(6): 506-510.
18.Nazemi, M., Ahmadi Taba, M.A., Pishevarzadeh, F., and Ahmadzadeh, O.
2010. Biological activity of secondary metabolites from Iophon sp. Journal od
Zanjan Biological Science. 4(3): 121-134.
19.Nazemi, M., Motellebi, A.A., Jamili, S., Mostafavi, P., and Mashinchian, A.
2013. Cytotoxic activity of diethylether extract of Ircinia sp. 1st national
congress on Marine Science Pasive Defence, Bandar Abbas, Iran.
20.Nazemi, M., Moradi, Y., Hossenzadeh, H., and Lakzaei, F. 2016. Cytotoxic
Activity of Natural Copmponents Soluble in Methanol and Diethyl ether of
Dysidea pallescens from Hengam Island, Persian Gulf. Iranian
Scientific Fisheries Journal. 4: 1-8.
21.Salimi, A., Saharkhiz, M.P., Motallebi, A., Seydi, E., Mohseni, A.R., Nazemi,
M., and Pourahmad, J. 2015. Standardized Extract of the Persian Gulf Sponge,
Axinella Sinoxea Selectively Induces Apoptosis through Mitochondria in
Human Chronic Lymphocytic Leukemia Cells. Journal of Analytical Oncology
4(4): 132-140.
22.Serlin, R.C., Mendoza, T.R., Nakamura, Y., Edwards, K.R., and Cleeland, C.S.
1995. When is cancer pain mild, moderate or severe? Grading pain severity by
its interference with function. Pain 61(2): 277-284.
23.Siegel, R.L., Miller, K.D., and Jemal, A. 2016. Cancer statistics, 2016. CA: a
cancer journal for clinicians. 66(1): 7-30.
24.Sipkema, D., Franssen, M.C., Osinga, Tramper, R.J., and Wijffels, R.H. 2005.
Marine sponges as pharmacy. Marine Biotechnology 7(3): 142-162.
25.Su, J., Meng, Y., Zeng, Fu, L.X., and Schmitz, F. 1994. Stellettin A, a new
triterpenoid pigment from the marine sponge Stelletta tenuis. Journal of natural
products. 57(10): 1450-1451.
26.Takahashi, Y., Ushio, M., Kubota, T., Yamamoto, S., Fromont, J., and
Kobayashi, J.I. 2009. Nakijiquinones J− R, Sesquiterpenoid Quinones with an
Amine Residue from Okinawan Marine Sponges†. Journal of natural products
73(3): 467-471.
27.Thakur, N.L., Thakur, A.N., and Muller, W. 2005. Marine natural products in
drug discovery. Nat. Prod. Radiance 4(6): 471-477.
28.Zapata, A., and Amemiya, C. 2000. Phylogeny of lower vertebrates and their
immunological structures. In Origin and evolution of the vertebrate immune
system: Springer, 67-107.