Effect of pesticide Glyophosate on histological lesions of kidney in common carp (Cyprinus carpio)

Document Type : scientific research article

Abstract

Abstract. Glyphosate is one of the most used pesticides in the agriculture. This study was aimed to evaluate the effect of pesticide glyphosate on histopathology of kidney in common carp (Cyprinus carpio). To this aim, glyphosate treatments were 0, 6, 7, and 8 mg of each treatment with three replications. 150 pieces of fish with an average weight of 30 ±5 were randomly divided in 12 of the 80 liter tank with 40 liters. At the end of the 70 days growing period for study of histopathological lesions of kidney, anesthetic of clove powder samples of kidney were performed. Histopathologic examination results showed that significant changes in kidney were performed. Renal tubular necrosis begins to accumulate of congestion; destruction and necrosis of tubular epithelial cells hemorrhage and congestion were observed in the urinary tract. In General, result confirmed that chronic concentrations of glyphosate had more physiologic effects like histopathological lesions on common carp like renal tubular necrosis, bleeding and renal tubular necrosis and urethral hypertension; these changes can be used as bio-indicator of glyphosate effects of this fish.

Keywords

Main Subjects


 1. Agius, C., and Roberts, R.J. 2003. Melano-macrophage centres and their role in fish pathology. Journal of Fish Disease, 26: 499–509.
2. Altinok, I., and Capkin, E. 2008. Histopathology of Rainbow Trout Exposed to Sublethal Concentrations of Methiocarb or Endosulfan. Review Aquatic Science, 4: 210–223.
3. Arunkumar, R.I., Rajasekaran, P., and Michael, R.D. 2000. Differential effect of chromium compounds on the immune response of the African mouth breeder Oreochromismossambicus (Peters). Fish and Shellfish Immunology, 10: 667–676.
4. Ayoola, S.O. 2008. Histopathological effects of Glyphosate on juvenile African catfish (clarias goriepis). American- Eurasian, J. Agric. And Enuiron. Sci., vol. 4(3): 362-367.
5. Beyenbach, K.W. 1995. Secretory electrolyte transport in renal proximal tubules of fish. In Cellular and Molecular Approaches to Fish Ionic Regulation, Wood, C.M., and Shuttleworth, T.J., Eds., Academic Press, New York, Pp: 85–103.
6. Di Giulio, R.T., and Hinton, D.E. 2008. The Toxicology of FishesS. Taylor and Francis Group. 1101p.
7. Figueiredo-Fernandes, A., Ferreira-Cardoso, J.V., Garcia-Santos, S., Monteiro, S.M., Carrola, J., Matos, P., Fontainhas-Fernandes, A., 2007. Histopathological changes in liver and gill epithelium of Nile tilapia, Oreochromis niloticus, exposed to waterborne copper.Pesqui. Vet. Bras. 27(3): 103–109.
8. Folmar, L.C., Sanders, H.O., and Julin, A.M. 1979. Toxicity of the herbicide glyphosate and several of its formulations to fish and aquatic invertebrates .Archives of Environmental Contamination and Toxicology, 8: 269-278.
9. Gad, S.C. 2007. Animal Models in Toxicology. CRC Press. 950p.
10.Gold Sborough, L.G., and Brown, D.J. 1993. Dissipation of glyphosate and amino methyl phonic acid in water and sediments of boreal forest ponds environment toxicology and chemistry, 12: 1139-1147.
11.Hinton, D.E., and Laurén, D.J. 1990. Liver structural alterations accompanying chronic
toxicity in fishes: potentioal biomarkers of exposure. Pp. 51-65. In: McCarthy, J.F., and L.R., Shugart (Eds.).
12.Kakkar, K.G. 2011. Water soluble fraction of diesel fuel induced histopathological
alterations in the liver of Channa punctatus. Fish and Shellfish Immunology, 18: 14-16.
13.Neskovic, N.K., Poleksic, V., Elezovic, I., Karan, V., Budimit, M. 1995. Biochemical and Histopathological effect of Glyphosate on carp, cyprinuscarpiol: Environmental contamination and toxicology. 56: 295-302.